Prostate Cancer - Tomato And Soy Products May Aid In Treatment

eNews from Friday, May 30, 2008

Tomato and Soy Products May Aid in Treatment for Prostate Cancer Claim Scientists at Ohio State University

2008 JUN 3 - www.newsrx.com -- "Tomato and soy products are hypothesized to reduce the risk of prostate cancer or enhance efficacy of therapy see also --www.newsrx.com/library/topics/Prostate-Cancer.html. A study was completed to determine if men with active prostate cancer will adhere to a dietary intervention rich in tomato products and a soy protein supplement men (n = 41) with recurrent, asymptomatic prostate cancer were randomized among 2 groups: Group A (n = 20) consumed tomato products (no soy) for Weeks 0 through 4, targeting a minimum of 25 mg of lycopene/day," scientists in the United States report.

"Group B (n = 21) consumed soy (no tomatoes) for Weeks 0 through 4, providing 40 g of soy protein/day. For Weeks 4 through 8, all men consumed a combined tomato-rich diet and soy supplements. No grade II through IV toxicities were observed. During Weeks 0 through 4, mean daily lycopene intake for Group A was 43 mg ( 15 mg) and mean soy intake for Group B was 39 g ( 1 g), remaining similar during Weeks 4 through 8. Serum lycopene increased from 0.72 +/- 0.09 mu mol/l to 1.21 +/- 0.10 mu mol/l (P < 0.0001) and urinary isoflavone excretion increased from not detectable to 54.1 +/- 5.7 mu mol/l (P < 0.05) with 8 wk of diet intervention. Serum prostate-specific antigen decreased between Weeks 0 and 8 for 14/41 men (34%). Mean serum vascular endothelial growth factor for the entire group was reduced from 87 to 51 ng/ml (P < 0.05) over 8 wk," wrote E.M. Grainger and colleagues, Ohio State University.

The researchers concluded: "Prostate cancer patients will consume diets rich in tomato products and soy with excellent compliance and bioavailability of phytochemicals. Further studies combining tomato and soy foods to determine efficacy for prostate cancer prevention or management are encouraged."

Grainger and colleagues published their study in Nutrition and Cancer - an International Journal (A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen. Nutrition and Cancer - an International Journal, 2008;60(2):145-154).

For more information, contact S.K. Clinton, Ohio State University, Division Hematology Oncology, 320 W 10th Avenue, A434 Starling Loving Hall, Columbus, OH 43210, USA.

Publisher contact information for the Nutrition and Cancer - an International Journal is: Lawrence Erlbaum Association Inc-Taylor & Francis, 325 Chestnut Street, Ste. 800, Philadelphia, PA 19106, USA.

Copyright 2008 Cancer Weekly via NewsRx.com


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